Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging Exclusive	pancan	1.50e-10	3.25e-01	9.25e-16	1.60e-16
pancan Exclusive	aging	4.19e-03	4.84e-02	7.14e-04	2.40e-01
aging Exclusive	pancan Exclusive	2.19e-10	4.79e-01	4.89e-14	3.33e-16
pancan Exclusive	aging Exclusive	1.87e-03	3.42e-02	1.23e-03	1.25e-01
aging Exclusive	Overlap	9.90e-01	1.98e-02	9.11e-01	1.98e-01
pancan Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	4.58e-24	3.41e-20	4.21e-104	1.46e-70



Evaluating how well aging genes are linked to pancan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging Exclusive	pancan	0.68	-0.09	1.24	-1.03	7.94
pancan Exclusive	aging	0.48	0.69	-1.01	-0.68	-0.47
aging Exclusive	pancan Exclusive	0.68	-0.08	0.84	-0.81	8.32
pancan Exclusive	aging Exclusive	0.47	0.41	-1.12	-0.75	-0.95
aging Exclusive	Overlap	0.86	0.33	1.98	0.15	1.55
pancan Exclusive	Overlap	1.00	1.44	1.25	1.06	1.70
Overlap	Exclusives	0.79	3.24	6.97	2.21	14.46

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging Exclusive	pancan	0.02	-0.14	1.30	-0.83	6.66
pancan Exclusive	aging	0.00	6.50	6.42	0.88	0.81
aging Exclusive	pancan Exclusive	0.02	-0.05	1.06	-0.68	8.19
pancan Exclusive	aging Exclusive	0.00	1.08	0.06	-0.46	-0.70
aging Exclusive	Overlap	0.00	-0.29	3.54	-0.30	0.56
pancan Exclusive	Overlap	0.10	13.58	116.45	53.04	258.47
Overlap	Exclusives	0.05	4.74	17.33	3.31	28.65

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging Exclusive	59	58	MUC19
pancan Exclusive	199	199	
Overlap	1	1