Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	geneAgeAll	6.12e-03	4.44e-09	1.85e-02	3.21e-41
geneAgeAll	aging	2.15e-01	3.84e-02	5.65e-05	3.57e-01



Evaluating how well aging genes are linked to geneAgeAll genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	geneAgeAll	0.76	1.67	7.17	1.53	14.99
geneAgeAll	aging	0.49	1.36	-1.06	-0.45	-0.12

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	geneAgeAll	0.04	1.21	7.87	1.25	20.32
geneAgeAll	aging	0.00	2.34	0.22	-0.06	0.68

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	64	64	
geneAgeAll	307	306	TERC