Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	pancan	1.82e-05	1.19e-02	3.67e-03	1.23e-25
pancan	aging	1.73e-01	2.49e-03	3.58e-04	2.43e-02



Evaluating how well aging genes are linked to pancan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	pancan	0.73	0.07	3.11	0.46	12.52
pancan	aging	0.45	0.64	-2.32	-0.79	-1.36

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	pancan	0.02	-0.43	3.03	-0.03	8.95
pancan	aging	0.00	0.39	-1.14	-0.44	-0.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	64	64	
pancan	200	200