Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	ad_gwas	3.67e-01	2.86e-01	3.26e-01	1.28e-02
ad_gwas	aging	2.22e-01	5.76e-02	2.25e-02	1.91e-02



Evaluating how well aging genes are linked to ad_gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	ad_gwas	0.68	1.41	2.20	0.85	2.95
ad_gwas	aging	0.65	2.48	2.63	1.74	2.49

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	ad_gwas	0.00	1.08	1.75	0.02	1.89
ad_gwas	aging	0.00	0.74	0.14	0.16	1.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	27	27	
ad_gwas	25	25