Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	tier1_ad	1.73e-01	2.55e-02	5.47e-02	6.06e-04
tier1_ad	aging	4.48e-01	4.98e-02	3.16e-02	3.69e-03



Evaluating how well aging genes are linked to tier1_ad genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	tier1_ad	0.70	1.96	2.61	1.39	3.96
tier1_ad	aging	0.63	0.98	2.89	1.56	3.75

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	tier1_ad	0.00	1.18	-0.05	0.40	2.83
tier1_ad	aging	0.01	0.63	0.70	1.20	3.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	67	67	
tier1_ad	31	30	MS4A