Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	genAgeAll	4.35e-04	1.29e-05	6.34e-11	3.30e-45
genAgeAll	aging	3.54e-02	2.42e-01	8.15e-09	6.11e-03



Evaluating how well aging genes are linked to genAgeAll genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	genAgeAll	0.76	0.50	5.88	1.74	15.53
genAgeAll	aging	0.63	3.61	2.39	2.06	3.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	genAgeAll	0.04	-0.38	6.82	1.35	22.37
genAgeAll	aging	0.01	2.15	1.46	2.32	2.43

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	67	67	
genAgeAll	307	306	TERC