Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	25_ad_gwas	2.98e-02	6.00e-01	2.86e-03	1.07e-01
25_ad_gwas	aging	1.19e-01	7.04e-01	3.15e-01	4.65e-01



Evaluating how well aging genes are linked to 25_ad_gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	25_ad_gwas	0.59	0.08	0.51	-0.47	1.62
25_ad_gwas	aging	0.48	0.35	-0.99	-0.27	-0.74

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	25_ad_gwas	0.00	-0.38	-0.21	-0.58	-0.20
25_ad_gwas	aging	0.00	-0.21	-0.93	-0.42	-0.49

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	66	65	MUC19
25_ad_gwas	25	25