Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	pancan	1.24e-18	1.80e-01	3.20e-29	7.73e-12
pancan	aging	1.23e-03	6.26e-03	4.19e-04	2.30e-03



Evaluating how well aging genes are linked to pancan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	pancan	0.61	-1.73	-1.83	-2.94	4.82
pancan	aging	0.37	-0.76	-3.35	-1.88	-3.76

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	pancan	0.01	-1.53	-1.90	-1.76	1.79
pancan	aging	0.00	-0.89	-0.42	-0.81	-1.62

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	66	65	MUC19
pancan	200	200