Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	geneAgeAll	6.12e-14	1.71e-02	1.92e-22	7.49e-30
geneAgeAll	aging	1.98e-01	6.29e-01	6.45e-02	1.07e-01



Evaluating how well aging genes are linked to geneAgeAll genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	geneAgeAll	0.67	0.10	3.59	-0.88	9.31
geneAgeAll	aging	0.47	2.48	-0.92	-0.72	-0.93

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	geneAgeAll	0.02	-0.20	4.01	-0.96	5.09
geneAgeAll	aging	0.00	3.18	-0.83	-0.54	-0.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	66	65	MUC19
geneAgeAll	307	306	TERC