Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	25_ad_gwas	6.87e-01	7.54e-01	5.93e-01	4.66e-02
25_ad_gwas	aging	1.95e-01	3.95e-02	3.58e-02	3.32e-02



Evaluating how well aging genes are linked to 25_ad_gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	25_ad_gwas	0.65	0.84	0.87	0.52	2.47
25_ad_gwas	aging	0.65	2.51	2.49	1.62	2.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	25_ad_gwas	0.00	0.67	0.71	0.43	0.73
25_ad_gwas	aging	0.00	1.23	0.06	0.44	0.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	22	22	
25_ad_gwas	25	25