Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	tier1	6.08e-01	2.61e-01	2.28e-01	3.83e-02
tier1	aging	2.46e-01	5.77e-02	5.97e-02	1.54e-02



Evaluating how well aging genes are linked to tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	tier1	0.64	0.74	1.86	0.74	2.75
tier1	aging	0.65	1.50	1.88	1.30	2.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	tier1	0.00	1.20	1.27	0.70	0.62
tier1	aging	0.00	0.25	-0.02	0.02	1.33

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	22	22	
tier1	31	30	MS4A