Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	genAgeAll	4.27e-09	1.45e-13	8.44e-24	3.25e-75
genAgeAll	aging	2.04e-01	3.89e-01	1.03e-03	1.32e-01



Evaluating how well aging genes are linked to genAgeAll genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	genAgeAll	0.81	2.59	11.02	3.06	18.53
genAgeAll	aging	0.58	2.86	1.03	0.80	1.30

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	genAgeAll	0.04	2.68	13.73	3.76	26.92
genAgeAll	aging	0.00	8.04	5.11	5.71	6.95

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	22	22	
genAgeAll	307	306	TERC