Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	25_ad_gwas	3.51e-02	8.25e-01	1.37e-02	3.76e-02
25_ad_gwas	aging	8.84e-02	8.22e-01	6.08e-01	5.29e-01



Evaluating how well aging genes are linked to 25_ad_gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	25_ad_gwas	0.61	0.13	0.35	-0.11	1.93
25_ad_gwas	aging	0.52	0.28	0.03	-0.20	0.57

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	25_ad_gwas	0.00	-0.20	-0.20	-0.48	-0.02
25_ad_gwas	aging	0.00	-0.17	-0.30	-0.52	-0.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	44	44	
25_ad_gwas	25	25