Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	tier1_ad	2.67e-02	8.82e-02	1.26e-02	2.07e-03
tier1_ad	aging	1.25e-01	6.64e-01	6.51e-01	4.16e-01



Evaluating how well aging genes are linked to tier1_ad genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	tier1_ad	0.61	0.56	1.19	0.38	2.44
tier1_ad	aging	0.52	0.28	-0.21	-0.07	0.36

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	tier1_ad	0.00	-0.14	-0.12	-0.19	0.34
tier1_ad	aging	0.00	-0.10	-0.42	-0.45	-0.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	44	44	
tier1_ad	31	30	MS4A