Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) aging genAgeAll 1.35e-09 2.53e-02 3.96e-10 1.96e-38 genAgeAll aging 6.54e-02 7.27e-01 7.04e-03 2.53e-01 Evaluating how well aging genes are linked to genAgeAll genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) aging genAgeAll 0.70 0.22 3.06 -0.04 12.65 genAgeAll aging 0.54 2.92 0.50 0.55 0.96 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) aging genAgeAll 0.03 -0.13 2.98 -0.29 11.62 genAgeAll aging 0.00 3.71 0.09 0.01 -0.21 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes aging 44 44 genAgeAll 307 306 TERC