Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	pancan	8.49e-16	3.43e-02	6.38e-18	1.54e-15
pancan	aging	1.46e-03	4.61e-02	7.30e-02	1.44e-02



Evaluating how well aging genes are linked to pancan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	pancan	0.63	-1.70	-3.00	-2.05	6.38
pancan	aging	0.41	-2.08	-2.79	-1.71	-2.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	pancan	0.01	-1.37	-2.83	-1.53	2.67
pancan	aging	0.00	-1.73	-0.31	-1.06	-1.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	44	44	
pancan	200	200