Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
intersection_39_full Exclusive	tier1_31	1.47e-14	1.58e-14	4.00e-17	1.35e-16
tier1_31 Exclusive	intersection_39_full	6.45e-03	4.61e-03	3.99e-04	1.56e-06
intersection_39_full Exclusive	tier1_31 Exclusive	7.82e-12	1.99e-13	1.63e-15	2.91e-14
tier1_31 Exclusive	intersection_39_full Exclusive	2.96e-02	1.02e-02	2.18e-03	1.78e-05
intersection_39_full Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	6.89e-11	4.25e-12	2.40e-21	2.65e-14



Evaluating how well intersection_39_full genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
intersection_39_full Exclusive	tier1_31	0.92	6.42	8.21	5.49	8.74
tier1_31 Exclusive	intersection_39_full	0.75	4.01	3.81	3.98	5.08
intersection_39_full Exclusive	tier1_31 Exclusive	0.91	6.15	9.17	4.65	7.28
tier1_31 Exclusive	intersection_39_full Exclusive	0.73	3.82	3.46	3.53	4.54
intersection_39_full Exclusive	Overlap	1.00	2.87	2.67	3.03	3.11
tier1_31 Exclusive	Overlap	1.00	3.32	2.74	2.89	3.24
Overlap	Exclusives	0.83	4.58	9.08	3.44	9.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
intersection_39_full Exclusive	tier1_31	0.12	158.36	162.52	195.44	215.92
tier1_31 Exclusive	intersection_39_full	0.08	121.93	150.11	170.39	118.32
intersection_39_full Exclusive	tier1_31 Exclusive	0.08	129.53	78.09	117.44	171.99
tier1_31 Exclusive	intersection_39_full Exclusive	0.06	120.65	121.07	162.74	95.71
intersection_39_full Exclusive	Overlap	0.06	95.71	145.02	140.38	170.42
tier1_31 Exclusive	Overlap	0.10	217.50	100.45	344.40	864.88
Overlap	Exclusives	0.19	140.74	354.86	149.36	396.64

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
intersection_39_full Exclusive	36	36	
tier1_31 Exclusive	28	27	MS4A
Overlap	3	3