Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Genegroup1	Genegroup2	4.50e-01	5.66e-01	1.00e-01	8.25e-01
Genegroup2	Genegroup1	9.58e-01	9.00e-01	9.85e-01	5.24e-01



Evaluating how well Genegroup1 genes are linked to Genegroup2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Genegroup1	Genegroup2	0.54	-0.47	-0.34	-0.85	0.23
Genegroup2	Genegroup1	0.38	-0.47	-0.35	-1.02	-0.93

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Genegroup1	Genegroup2	0.00	-0.41	-0.38	-0.54	-0.31
Genegroup2	Genegroup1	0.00	-0.35	-0.32	-0.28	-0.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Genegroup1	5	5	
Genegroup2	4	3	Parkin