Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
intersection_36 Exclusive	ad_tier1_36	4.34e-12	1.11e-12	2.36e-12	1.40e-12
ad_tier1_36 Exclusive	intersection_36	3.01e-02	1.54e-01	2.95e-02	4.82e-02
intersection_36 Exclusive	ad_tier1_36 Exclusive	2.29e-11	9.16e-12	7.32e-12	6.03e-12
ad_tier1_36 Exclusive	intersection_36 Exclusive	6.33e-02	1.40e-01	7.77e-02	1.10e-01
intersection_36 Exclusive	Overlap	1.19e-01	1.98e-02	7.92e-02	3.96e-02
ad_tier1_36 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	5.36e-05	2.71e-07	1.47e-23	6.10e-08



Evaluating how well intersection_36 genes are linked to ad_tier1_36 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
intersection_36 Exclusive	ad_tier1_36	0.85	4.32	6.98	3.59	6.77
ad_tier1_36 Exclusive	intersection_36	0.58	1.91	1.48	1.79	2.04
intersection_36 Exclusive	ad_tier1_36 Exclusive	0.84	3.85	7.21	4.31	6.05
ad_tier1_36 Exclusive	intersection_36 Exclusive	0.57	2.37	1.36	1.32	1.56
intersection_36 Exclusive	Overlap	0.98	1.30	428925356814662.50	1.40	1.55
ad_tier1_36 Exclusive	Overlap	1.00	1.24	inf	1.50	1.81
Overlap	Exclusives	0.73	831933469991836.00	7.32	2.38	6.30

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
intersection_36 Exclusive	ad_tier1_36	0.03	40.34	82.23	40.69	58.97
ad_tier1_36 Exclusive	intersection_36	0.03	47.34	59.71	74.65	82.92
intersection_36 Exclusive	ad_tier1_36 Exclusive	0.03	45.71	95.82	34.47	20.86
ad_tier1_36 Exclusive	intersection_36 Exclusive	0.03	89.64	46.13	9.89	61.63
intersection_36 Exclusive	Overlap	0.00	2.30	46579744815323384.00	2.86	5.96
ad_tier1_36 Exclusive	Overlap	0.02	17.48	151272923003761312.00	45.92	27.75
Overlap	Exclusives	0.02	19972837005544284.00	34.96	8.46	38.75

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
intersection_36 Exclusive	35	34	RFPL2
ad_tier1_36 Exclusive	30	29	MS4A
Overlap	1	1