Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma28	GSall	1.51e-02	2.68e-01	1.72e-08	3.96e-14
GSall	sigma28	6.81e-01	2.84e-01	2.01e-03	8.12e-03



Evaluating how well sigma28 genes are linked to GSall genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma28	GSall	0.69	1.60	2.28	1.89	9.88
GSall	sigma28	0.63	0.57	1.21	1.37	2.79

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma28	GSall	0.02	1.26	1.95	1.88	6.25
GSall	sigma28	0.00	-1.03	2.17	0.95	1.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma28	28	28	
GSall	203	180	COLCA1;SnoU13;LINC00675;METRLN; MYNN;CDKN2B-AS1;LINC00917;LINC00673;ANRIL;HLA class I;45358;c11orf53; PIGU;RTELI;ZMIZ1-AS1;HLA class II;TERC;SCL22A3;SNHG15;LOC146513;LINC00603;POUF5F1B;SAT2B-AS1