Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma36	GSall	4.95e-04	4.87e-02	3.05e-09	2.65e-14
GSall	sigma36	2.40e-01	5.96e-02	3.87e-05	3.21e-03



Evaluating how well sigma36 genes are linked to GSall genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma36	GSall	0.70	2.46	3.22	2.03	9.27
GSall	sigma36	0.65	1.64	2.10	2.53	3.49

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma36	GSall	0.02	2.64	4.18	2.85	12.51
GSall	sigma36	0.00	0.02	2.08	1.41	2.90

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma36	36	36	
GSall	203	180	HLA class II;LINC00673;SnoU13;LOC146513;COLCA1;ZMIZ1-AS1;LINC00917; MYNN;POUF5F1B;c11orf53;CDKN2B-AS1;SAT2B-AS1;RTELI;SNHG15;LINC00675; PIGU;SCL22A3;METRLN;TERC;ANRIL;45358;LINC00603;HLA class I