Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma36	GSfam	4.27e-02	1.84e-01	1.32e-03	3.13e-07
GSfam	sigma36	5.20e-01	1.13e-01	2.11e-02	6.53e-03



Evaluating how well sigma36 genes are linked to GSfam genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma36	GSfam	0.79	1.11	2.12	1.38	6.43
GSfam	sigma36	0.66	2.34	2.27	2.05	3.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma36	GSfam	0.01	1.46	4.59	2.17	1.60
GSfam	sigma36	0.00	0.72	1.58	1.74	1.76

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma36	36	36	
GSfam	35	35