Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma252 Exclusive	GSfam	6.77e-01	6.97e-01	1.45e-01	1.80e-07
GSfam Exclusive	sigma252	3.69e-05	4.11e-01	2.66e-05	3.13e-02
sigma252 Exclusive	GSfam Exclusive	5.54e-01	7.00e-01	1.64e-01	1.53e-06
GSfam Exclusive	sigma252 Exclusive	1.09e-04	5.19e-01	5.06e-06	6.19e-02
sigma252 Exclusive	Overlap	8.17e-01	4.78e-01	4.49e-01	2.24e-01
GSfam Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	1.08e-02	5.45e-03	4.38e-16	2.49e-06



Evaluating how well sigma252 genes are linked to GSfam genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma252 Exclusive	GSfam	0.77	0.32	0.70	0.65	5.63
GSfam Exclusive	sigma252	0.55	1.75	1.60	1.51	2.78
sigma252 Exclusive	GSfam Exclusive	0.77	0.54	0.92	0.82	4.94
GSfam Exclusive	sigma252 Exclusive	0.54	1.79	1.30	1.35	2.24
sigma252 Exclusive	Overlap	0.73	0.23	-0.09	0.40	1.14
GSfam Exclusive	Overlap	1.00	2.21	2.17	2.04	2.45
Overlap	Exclusives	0.60	1.79	3.98	2.37	5.68

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma252 Exclusive	GSfam	0.01	0.52	2.63	0.93	1.83
GSfam Exclusive	sigma252	0.02	2.31	3.55	2.45	4.67
sigma252 Exclusive	GSfam Exclusive	0.01	0.68	3.05	1.91	2.52
GSfam Exclusive	sigma252 Exclusive	0.01	1.21	0.67	0.81	1.45
sigma252 Exclusive	Overlap	0.00	-0.28	-0.73	-0.22	-0.06
GSfam Exclusive	Overlap	0.18	1041.82	674.65	395.52	414.15
Overlap	Exclusives	0.03	9.61	16.49	9.94	19.50

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma252 Exclusive	250	248	MFRP;AC004076.1
GSfam Exclusive	33	33	
Overlap	2	2