Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sen	51	4.70e-11	5.60e-02	4.72e-04	2.60e-02
51	Sen	1.85e-18	2.76e-09	7.40e-01	1.02e-04



Evaluating how well Sen genes are linked to 51 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sen	51	0.58	-6.64	-2.12	-1.62	2.18
51	Sen	0.56	-4.09	-8.53	-1.02	2.45

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sen	51	0.00	-1.46	-2.30	-1.57	0.02
51	Sen	0.01	-1.45	-5.09	-0.84	0.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sen	124	123	CCL3L1
51	51	48	CHD2;USP9Y;NLGN4Y