Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_wgs_z3_161 Exclusive	Isamel_14_AD	8.06e-01	9.23e-01	7.73e-01	2.09e-02
Isamel_14_AD Exclusive	sigma_wgs_z3_161	1.82e-02	9.94e-01	1.79e-07	9.18e-01
sigma_wgs_z3_161 Exclusive	Isamel_14_AD Exclusive	8.16e-01	9.19e-01	9.50e-01	5.12e-02
Isamel_14_AD Exclusive	sigma_wgs_z3_161 Exclusive	1.82e-02	9.86e-01	7.18e-07	9.39e-01
sigma_wgs_z3_161 Exclusive	Overlap	6.53e-01	5.54e-01	6.34e-01	5.54e-01
Isamel_14_AD Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	8.88e-04	1.19e-01	6.41e-07	1.67e-01



Evaluating how well sigma_wgs_z3_161 genes are linked to Isamel_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_wgs_z3_161 Exclusive	Isamel_14_AD	0.71	0.54	0.56	0.66	2.90
Isamel_14_AD Exclusive	sigma_wgs_z3_161	0.50	0.11	-0.23	0.03	0.20
sigma_wgs_z3_161 Exclusive	Isamel_14_AD Exclusive	0.71	0.77	0.26	0.49	2.41
Isamel_14_AD Exclusive	sigma_wgs_z3_161 Exclusive	0.50	0.22	-0.54	-0.11	0.09
sigma_wgs_z3_161 Exclusive	Overlap	0.73	0.64	0.66	0.69	0.79
Isamel_14_AD Exclusive	Overlap	1.00	5.52	1.60	2.05	1.71
Overlap	Exclusives	0.50	-0.34	-0.75	-0.33	-0.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_wgs_z3_161 Exclusive	Isamel_14_AD	0.00	-0.17	0.17	0.17	0.82
Isamel_14_AD Exclusive	sigma_wgs_z3_161	0.01	3.82	2.63	3.09	2.87
sigma_wgs_z3_161 Exclusive	Isamel_14_AD Exclusive	0.00	-0.10	0.39	-0.05	0.45
Isamel_14_AD Exclusive	sigma_wgs_z3_161 Exclusive	0.01	0.44	0.07	0.13	0.03
sigma_wgs_z3_161 Exclusive	Overlap	0.00	-0.18	-0.16	-0.05	-0.11
Isamel_14_AD Exclusive	Overlap	0.25	1828.71	437.94	580.56	170.18
Overlap	Exclusives	0.02	6.40	12.29	4.54	10.55

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_wgs_z3_161 Exclusive	160	159	CHURC1-FNTB
Isamel_14_AD Exclusive	13	13	
Overlap	1	1