Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
SpliceAI 05	AD	4.92e-01	3.67e-01	5.63e-01	2.58e-02
AD	SpliceAI 05	4.10e-01	6.97e-01	5.29e-02	7.16e-01



Evaluating how well SpliceAI 05 genes are linked to AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SpliceAI 05	AD	0.62	0.52	0.28	0.03	2.19
AD	SpliceAI 05	0.52	0.82	0.88	1.16	0.72

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SpliceAI 05	AD	0.00	-0.17	-0.47	-0.41	0.22
AD	SpliceAI 05	0.00	-0.17	0.11	-0.15	-0.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
SpliceAI 05	76	76	
AD	25	25