Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
SpliceAI 0 Exclusive	AD	1.28e-03	9.56e-03	5.99e-03	2.85e-05
AD Exclusive	SpliceAI 0	4.44e-01	8.86e-02	3.83e-03	2.27e-02
SpliceAI 0 Exclusive	AD Exclusive	6.37e-04	3.75e-03	3.46e-03	1.80e-04
AD Exclusive	SpliceAI 0 Exclusive	5.04e-01	1.10e-01	3.18e-03	3.76e-02
SpliceAI 0 Exclusive	Overlap	6.67e-01	9.08e-01	9.28e-01	2.48e-01
AD Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	5.34e-02	2.03e-02	4.75e-17	2.17e-03



Evaluating how well SpliceAI 0 genes are linked to AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SpliceAI 0 Exclusive	AD	0.76	2.75	3.86	2.58	4.45
AD Exclusive	SpliceAI 0	0.55	1.93	1.92	1.77	2.02
SpliceAI 0 Exclusive	AD Exclusive	0.77	3.21	3.70	1.94	4.27
AD Exclusive	SpliceAI 0 Exclusive	0.54	1.35	1.65	1.47	1.69
SpliceAI 0 Exclusive	Overlap	0.75	0.68	0.29	0.41	1.43
AD Exclusive	Overlap	1.00	3.18	2.17	2.64	2.75
Overlap	Exclusives	0.58	2.96	3.15	1.99	3.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SpliceAI 0 Exclusive	AD	0.00	3.86	5.56	3.45	7.25
AD Exclusive	SpliceAI 0	0.01	2.91	5.83	5.54	5.43
SpliceAI 0 Exclusive	AD Exclusive	0.00	5.53	5.67	1.96	2.40
AD Exclusive	SpliceAI 0 Exclusive	0.01	2.01	4.29	1.92	1.65
SpliceAI 0 Exclusive	Overlap	0.00	0.36	-0.08	0.35	0.67
AD Exclusive	Overlap	0.03	134.62	61.77	134.58	26.33
Overlap	Exclusives	0.03	23.59	28.63	22.15	15.05

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
SpliceAI 0 Exclusive	122	122	
AD Exclusive	22	22	
Overlap	3	3