Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Cauchy178 Exclusive	GS11	5.40e-01	6.10e-02	1.48e-04	1.49e-05
GS11 Exclusive	Cauchy178	5.77e-03	1.85e-02	1.27e-10	1.77e-11
Cauchy178 Exclusive	GS11 Exclusive	3.17e-01	1.48e-01	2.28e-04	2.12e-04
GS11 Exclusive	Cauchy178 Exclusive	1.65e-02	3.23e-02	2.06e-13	6.10e-11
Cauchy178 Exclusive	Overlap	1.50e-01	2.54e-01	2.71e-02	7.48e-02
GS11 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	5.25e-01	3.81e-01	5.70e-10	1.93e-10



Evaluating how well Cauchy178 genes are linked to GS11 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy178 Exclusive	GS11	0.85	0.40	2.30	1.63	4.42
GS11 Exclusive	Cauchy178	0.67	2.05	2.54	2.35	7.94
Cauchy178 Exclusive	GS11 Exclusive	0.89	1.16	2.51	2.18	4.15
GS11 Exclusive	Cauchy178 Exclusive	0.67	1.81	2.29	1.92	7.98
Cauchy178 Exclusive	Overlap	0.74	-0.63	0.81	0.51	1.53
GS11 Exclusive	Overlap	1.00	3.53	2.75	2.74	2.96
Overlap	Exclusives	0.66	1.24	1.57	1.01	7.80

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy178 Exclusive	GS11	0.00	-0.02	2.74	2.15	2.24
GS11 Exclusive	Cauchy178	0.02	5.57	5.83	8.85	17.21
Cauchy178 Exclusive	GS11 Exclusive	0.00	0.68	2.79	3.92	4.71
GS11 Exclusive	Cauchy178 Exclusive	0.02	1.70	1.91	3.49	5.86
Cauchy178 Exclusive	Overlap	0.00	-0.66	0.14	-0.18	0.01
GS11 Exclusive	Overlap	0.24	1282.18	392.53	476.53	748.31
Overlap	Exclusives	0.02	4.03	3.53	2.43	8.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Cauchy178 Exclusive	174	173	
GS11 Exclusive	8	8	
Overlap	3	3