Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma28	GSsom	9.23e-01	3.54e-01	1.49e-01	1.58e-04
GSsom	sigma28	2.88e-01	9.85e-01	7.52e-03	2.90e-01



Evaluating how well sigma28 genes are linked to GSsom genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma28	GSsom	0.77	0.31	-0.56	0.64	4.40
GSsom	sigma28	0.60	-0.08	0.19	0.49	1.88

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma28	GSsom	0.00	0.08	-0.25	0.66	0.90
GSsom	sigma28	0.00	-0.57	-0.05	0.15	0.56

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma28	28	28	
GSsom	20	20