Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GeneGroup1	GSsom	7.13e-02	1.83e-01	2.20e-02	5.60e-04
GSsom	GeneGroup1	1.39e-01	5.49e-01	1.76e-03	1.25e-01



Evaluating how well GeneGroup1 genes are linked to GSsom genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	GSsom	0.79	0.83	-0.16	0.74	4.43
GSsom	GeneGroup1	0.61	0.27	0.86	1.05	2.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	GSsom	0.01	2.04	4.44	2.58	12.76
GSsom	GeneGroup1	0.00	-0.14	1.51	1.25	1.49

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GeneGroup1	36	36	
GSsom	20	20