Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GeneGroup1	GSsom	4.38e-02	7.65e-02	2.17e-03	3.45e-06
GSsom	GeneGroup1	1.03e-01	5.36e-01	4.54e-06	7.28e-02



Evaluating how well GeneGroup1 genes are linked to GSsom genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	GSsom	0.82	1.10	1.56	1.59	5.37
GSsom	GeneGroup1	0.58	1.33	1.06	1.22	2.84

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	GSsom	0.01	4.67	9.83	7.89	32.26
GSsom	GeneGroup1	0.01	3.79	5.48	4.63	6.81

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GeneGroup1	83	82	MFRP
GSsom	20	20