Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GeneGroup1	GSsom	7.66e-01	6.02e-01	3.42e-01	1.48e-06
GSsom	GeneGroup1	2.71e-01	6.11e-01	4.76e-08	5.79e-01



Evaluating how well GeneGroup1 genes are linked to GSsom genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	GSsom	0.84	1.10	2.08	1.36	5.59
GSsom	GeneGroup1	0.52	1.71	0.48	0.97	0.49

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	GSsom	0.01	0.82	3.43	0.76	10.32
GSsom	GeneGroup1	0.01	1.60	0.82	0.43	0.83

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GeneGroup1	121	121	
GSsom	20	20