Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GeneGroup1	GSsom	2.52e-01	2.28e-01	1.74e-01	2.54e-07
GSsom	GeneGroup1	2.34e-01	5.56e-01	3.16e-10	1.76e-01



Evaluating how well GeneGroup1 genes are linked to GSsom genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	GSsom	0.87	1.99	2.42	1.89	5.65
GSsom	GeneGroup1	0.53	1.67	1.09	1.44	1.33

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	GSsom	0.01	1.45	6.01	2.03	19.78
GSsom	GeneGroup1	0.01	1.96	2.12	1.74	1.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GeneGroup1	152	151	11-Sep
GSsom	20	20