Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GeneGroup1	GSsom	3.83e-01	1.65e-01	3.45e-01	1.61e-06
GSsom	GeneGroup1	2.94e-02	2.59e-01	6.64e-27	2.50e-01



Evaluating how well GeneGroup1 genes are linked to GSsom genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	GSsom	0.86	1.02	1.48	1.25	5.70
GSsom	GeneGroup1	0.52	2.14	0.99	1.41	1.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	GSsom	0.02	0.30	1.82	0.94	14.56
GSsom	GeneGroup1	0.02	2.47	2.09	1.60	1.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GeneGroup1	352	351	11-Sep
GSsom	20	20