Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GeneGroup1	GSgwas	1.66e-02	1.10e-01	4.56e-06	4.25e-08
GSgwas	GeneGroup1	5.58e-01	4.60e-01	4.77e-03	6.63e-02



Evaluating how well GeneGroup1 genes are linked to GSgwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	GSgwas	0.67	1.95	2.62	1.91	6.00
GSgwas	GeneGroup1	0.62	0.73	1.29	1.61	2.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	GSgwas	0.01	1.71	2.19	2.14	3.24
GSgwas	GeneGroup1	0.00	0.10	1.98	1.35	1.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GeneGroup1	36	36	
GSgwas	157	134	LOC146513;SAT2B-AS1;HLA class II;METRLN;45358;LINC00673;LINC00603;RTELI;ANRIL;LINC00675;COLCA1; PIGU;LINC00917; MYNN;CDKN2B-AS1;SCL22A3;c11orf53;SNHG15;HLA class I;POUF5F1B;ZMIZ1-AS1;SnoU13;TERC