Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_EUR_WGS_withage_81 Exclusive	tier1_31	1.68e-01	3.41e-01	2.46e-01	2.76e-02
tier1_31 Exclusive	sigma_EUR_WGS_withage_81	2.36e-01	7.97e-01	6.09e-01	6.45e-01
sigma_EUR_WGS_withage_81 Exclusive	tier1_31 Exclusive	3.07e-01	4.78e-01	4.02e-01	1.07e-01
tier1_31 Exclusive	sigma_EUR_WGS_withage_81 Exclusive	2.24e-01	7.56e-01	7.35e-01	8.29e-01
sigma_EUR_WGS_withage_81 Exclusive	Overlap	4.07e-01	3.34e-01	2.48e-01	9.71e-02
tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	1.74e-06	8.71e-06
Overlap	Exclusives	1.12e-04	4.12e-04	2.91e-10	5.95e-05



Evaluating how well sigma_EUR_WGS_withage_81 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_withage_81 Exclusive	tier1_31	0.60	-0.10	0.51	0.25	1.77
tier1_31 Exclusive	sigma_EUR_WGS_withage_81	0.52	-0.07	-0.18	-0.05	0.85
sigma_EUR_WGS_withage_81 Exclusive	tier1_31 Exclusive	0.58	-0.19	0.14	-0.09	1.21
tier1_31 Exclusive	sigma_EUR_WGS_withage_81 Exclusive	0.50	-0.62	-0.83	-0.63	0.05
sigma_EUR_WGS_withage_81 Exclusive	Overlap	0.76	0.67	1.40	1.09	1.39
tier1_31 Exclusive	Overlap	1.00	3.12	2.51	2.62	2.87
Overlap	Exclusives	0.63	5.46	4.36	3.26	4.81

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_withage_81 Exclusive	tier1_31	0.00	-0.67	-0.36	-0.28	0.09
tier1_31 Exclusive	sigma_EUR_WGS_withage_81	0.01	2.81	0.66	3.83	3.75
sigma_EUR_WGS_withage_81 Exclusive	tier1_31 Exclusive	0.00	-0.55	-0.53	-0.28	0.08
tier1_31 Exclusive	sigma_EUR_WGS_withage_81 Exclusive	0.00	-0.35	-0.30	-0.49	-0.22
sigma_EUR_WGS_withage_81 Exclusive	Overlap	0.00	-0.35	0.62	-0.12	0.01
tier1_31 Exclusive	Overlap	0.04	103.55	142.37	59.98	29.76
Overlap	Exclusives	0.03	50.98	10.31	21.19	41.62

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_EUR_WGS_withage_81 Exclusive	78	77	CHURC1-FNTB
tier1_31 Exclusive	28	27	MS4A
Overlap	3	3