Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_EUR_WGS_withage_81 Exclusive	Isamel_14_AD	3.19e-01	2.07e-01	3.07e-01	7.27e-03
Isamel_14_AD Exclusive	sigma_EUR_WGS_withage_81	3.29e-03	5.76e-01	2.14e-04	6.41e-01
sigma_EUR_WGS_withage_81 Exclusive	Isamel_14_AD Exclusive	3.44e-01	1.96e-01	3.81e-01	1.79e-02
Isamel_14_AD Exclusive	sigma_EUR_WGS_withage_81 Exclusive	1.30e-03	5.35e-01	1.24e-04	7.09e-01
sigma_EUR_WGS_withage_81 Exclusive	Overlap	7.33e-01	9.90e-01	9.70e-01	9.11e-01
Isamel_14_AD Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	2.80e-02	1.64e-02	1.02e-04	2.36e-02



Evaluating how well sigma_EUR_WGS_withage_81 genes are linked to Isamel_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_withage_81 Exclusive	Isamel_14_AD	0.66	0.32	-0.36	0.19	2.26
Isamel_14_AD Exclusive	sigma_EUR_WGS_withage_81	0.50	-2.44	-0.87	-0.59	0.21
sigma_EUR_WGS_withage_81 Exclusive	Isamel_14_AD Exclusive	0.67	0.28	-0.43	0.35	1.88
Isamel_14_AD Exclusive	sigma_EUR_WGS_withage_81 Exclusive	0.50	-2.60	-1.05	-0.76	-0.02
sigma_EUR_WGS_withage_81 Exclusive	Overlap	0.54	0.23	-0.04	-0.14	0.09
Isamel_14_AD Exclusive	Overlap	1.00	5.71	1.48	2.97	1.92
Overlap	Exclusives	0.54	0.00	-0.36	0.09	1.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_withage_81 Exclusive	Isamel_14_AD	0.00	-0.60	-1.36	-0.47	0.27
Isamel_14_AD Exclusive	sigma_EUR_WGS_withage_81	0.01	1.13	4.25	2.33	6.78
sigma_EUR_WGS_withage_81 Exclusive	Isamel_14_AD Exclusive	0.00	-0.53	-1.33	-0.37	0.27
Isamel_14_AD Exclusive	sigma_EUR_WGS_withage_81 Exclusive	0.00	-0.58	-0.31	-0.27	-0.08
sigma_EUR_WGS_withage_81 Exclusive	Overlap	0.00	-0.24	-0.32	-0.29	-0.30
Isamel_14_AD Exclusive	Overlap	0.25	1736.86	407.01	1467.40	1266.25
Overlap	Exclusives	0.02	14.57	23.55	6.07	19.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_EUR_WGS_withage_81 Exclusive	80	79	CHURC1-FNTB
Isamel_14_AD Exclusive	13	13	
Overlap	1	1