Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_EUR_WGS_withage_164 Exclusive	Isamel_14_AD	9.96e-01	9.09e-01	9.94e-01	1.37e-01
Isamel_14_AD Exclusive	sigma_EUR_WGS_withage_164	5.28e-04	4.62e-01	6.93e-07	5.23e-01
sigma_EUR_WGS_withage_164 Exclusive	Isamel_14_AD Exclusive	9.98e-01	9.52e-01	9.13e-01	1.67e-01
Isamel_14_AD Exclusive	sigma_EUR_WGS_withage_164 Exclusive	3.47e-04	5.29e-01	5.64e-07	5.69e-01
sigma_EUR_WGS_withage_164 Exclusive	Overlap	9.50e-01	9.70e-01	9.31e-01	9.90e-01
Isamel_14_AD Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.25e-04	1.37e-01	1.17e-08	1.64e-01



Evaluating how well sigma_EUR_WGS_withage_164 genes are linked to Isamel_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_withage_164 Exclusive	Isamel_14_AD	0.65	-0.11	-0.68	-0.30	2.08
Isamel_14_AD Exclusive	sigma_EUR_WGS_withage_164	0.51	-0.93	-1.19	-0.78	0.26
sigma_EUR_WGS_withage_164 Exclusive	Isamel_14_AD Exclusive	0.66	0.07	-0.54	-0.36	1.95
Isamel_14_AD Exclusive	sigma_EUR_WGS_withage_164 Exclusive	0.50	-1.01	-1.17	-0.93	0.04
sigma_EUR_WGS_withage_164 Exclusive	Overlap	0.49	-0.03	-0.09	-0.13	-0.03
Isamel_14_AD Exclusive	Overlap	1.00	4.50	1.56	2.68	1.78
Overlap	Exclusives	0.52	-0.71	-0.58	-0.39	1.14

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_withage_164 Exclusive	Isamel_14_AD	0.00	0.08	0.76	0.12	0.06
Isamel_14_AD Exclusive	sigma_EUR_WGS_withage_164	0.01	1.23	2.50	2.66	2.73
sigma_EUR_WGS_withage_164 Exclusive	Isamel_14_AD Exclusive	0.00	0.21	0.88	0.24	1.89
Isamel_14_AD Exclusive	sigma_EUR_WGS_withage_164 Exclusive	0.01	-0.16	-0.25	-0.39	-0.06
sigma_EUR_WGS_withage_164 Exclusive	Overlap	0.00	-0.35	-0.39	-0.29	-0.31
Isamel_14_AD Exclusive	Overlap	0.25	582.10	561.30	1852.15	428.42
Overlap	Exclusives	0.02	7.79	11.22	6.55	6.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_EUR_WGS_withage_164 Exclusive	163	162	CHURC1-FNTB
Isamel_14_AD Exclusive	13	13	
Overlap	1	1