Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_EUR_WGS_excludin4cohort_76 Exclusive	ad_tier1_36	4.75e-01	3.48e-01	7.15e-01	9.91e-03
ad_tier1_36 Exclusive	sigma_EUR_WGS_excludin4cohort_76	3.23e-01	3.82e-01	3.09e-01	4.22e-01
sigma_EUR_WGS_excludin4cohort_76 Exclusive	ad_tier1_36 Exclusive	7.59e-01	4.63e-01	7.14e-01	4.21e-02
ad_tier1_36 Exclusive	sigma_EUR_WGS_excludin4cohort_76 Exclusive	2.24e-01	6.80e-01	2.51e-01	8.94e-01
sigma_EUR_WGS_excludin4cohort_76 Exclusive	Overlap	8.07e-01	2.88e-01	7.22e-01	3.41e-01
ad_tier1_36 Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	9.05e-07
Overlap	Exclusives	1.03e-03	5.90e-04	2.77e-09	2.71e-04



Evaluating how well sigma_EUR_WGS_excludin4cohort_76 genes are linked to ad_tier1_36 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_excludin4cohort_76 Exclusive	ad_tier1_36	0.61	0.53	0.51	0.22	2.37
ad_tier1_36 Exclusive	sigma_EUR_WGS_excludin4cohort_76	0.53	0.82	0.99	1.12	1.09
sigma_EUR_WGS_excludin4cohort_76 Exclusive	ad_tier1_36 Exclusive	0.60	0.30	0.64	0.16	1.71
ad_tier1_36 Exclusive	sigma_EUR_WGS_excludin4cohort_76 Exclusive	0.51	0.34	0.43	0.49	0.23
sigma_EUR_WGS_excludin4cohort_76 Exclusive	Overlap	0.68	0.07	0.03	0.18	1.16
ad_tier1_36 Exclusive	Overlap	1.00	2.93	2.73	2.75	3.62
Overlap	Exclusives	0.62	5.61	4.28	3.19	3.86

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_excludin4cohort_76 Exclusive	ad_tier1_36	0.00	-0.14	-0.33	-0.30	0.10
ad_tier1_36 Exclusive	sigma_EUR_WGS_excludin4cohort_76	0.01	4.80	7.59	5.71	2.03
sigma_EUR_WGS_excludin4cohort_76 Exclusive	ad_tier1_36 Exclusive	0.00	-0.18	-0.22	-0.23	0.12
ad_tier1_36 Exclusive	sigma_EUR_WGS_excludin4cohort_76 Exclusive	0.00	-0.07	0.21	-0.12	-0.21
sigma_EUR_WGS_excludin4cohort_76 Exclusive	Overlap	0.00	-0.52	-0.49	-0.46	-0.11
ad_tier1_36 Exclusive	Overlap	0.05	136.44	148.72	135.01	64.10
Overlap	Exclusives	0.03	74.14	23.57	29.73	43.52

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_EUR_WGS_excludin4cohort_76 Exclusive	72	71	CHURC1-FNTB
ad_tier1_36 Exclusive	27	26	MS4A
Overlap	4	4