Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_EUR_WGS_excludin4cohort_144 Exclusive	tier1_31	4.08e-02	7.04e-02	4.57e-02	1.53e-01
tier1_31 Exclusive	sigma_EUR_WGS_excludin4cohort_144	4.61e-01	7.44e-01	1.88e-01	5.64e-01
sigma_EUR_WGS_excludin4cohort_144 Exclusive	tier1_31 Exclusive	7.62e-02	1.09e-01	6.07e-02	4.00e-01
tier1_31 Exclusive	sigma_EUR_WGS_excludin4cohort_144 Exclusive	2.61e-01	4.75e-01	3.59e-01	4.56e-01
sigma_EUR_WGS_excludin4cohort_144 Exclusive	Overlap	6.56e-01	5.28e-01	5.54e-01	6.73e-01
tier1_31 Exclusive	Overlap	1.83e-09	1.83e-09	6.40e-08	2.74e-08
Overlap	Exclusives	2.34e-02	4.33e-02	4.72e-10	2.08e-02



Evaluating how well sigma_EUR_WGS_excludin4cohort_144 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_excludin4cohort_144 Exclusive	tier1_31	0.53	-1.28	-1.64	-1.03	0.68
tier1_31 Exclusive	sigma_EUR_WGS_excludin4cohort_144	0.52	0.22	0.05	0.65	0.76
sigma_EUR_WGS_excludin4cohort_144 Exclusive	tier1_31 Exclusive	0.51	-1.17	-1.70	-0.95	0.21
tier1_31 Exclusive	sigma_EUR_WGS_excludin4cohort_144 Exclusive	0.50	-0.22	-0.33	0.16	0.09
sigma_EUR_WGS_excludin4cohort_144 Exclusive	Overlap	0.60	-0.64	-0.94	-0.68	0.70
tier1_31 Exclusive	Overlap	1.00	2.73	2.81	2.86	3.76
Overlap	Exclusives	0.57	3.54	3.30	2.69	3.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_excludin4cohort_144 Exclusive	tier1_31	0.00	-0.74	-1.32	-0.62	-0.35
tier1_31 Exclusive	sigma_EUR_WGS_excludin4cohort_144	0.01	2.09	1.01	1.33	1.21
sigma_EUR_WGS_excludin4cohort_144 Exclusive	tier1_31 Exclusive	0.00	-1.14	-1.38	-0.78	-0.20
tier1_31 Exclusive	sigma_EUR_WGS_excludin4cohort_144 Exclusive	0.01	-0.81	-0.55	-0.62	-0.77
sigma_EUR_WGS_excludin4cohort_144 Exclusive	Overlap	0.00	-0.52	-0.68	-0.62	-0.07
tier1_31 Exclusive	Overlap	0.05	72.09	131.14	60.10	47.09
Overlap	Exclusives	0.03	26.66	10.88	23.06	24.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_EUR_WGS_excludin4cohort_144 Exclusive	140	139	CHURC1-FNTB
tier1_31 Exclusive	27	26	MS4A
Overlap	4	4