Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_EUR_WES_122	Isamel_14_AD	1.12e-01	2.02e-01	3.52e-02	7.55e-03
Isamel_14_AD	sigma_EUR_WES_122	1.13e-02	3.88e-01	7.27e-06	4.27e-02



Evaluating how well sigma_EUR_WES_122 genes are linked to Isamel_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WES_122	Isamel_14_AD	0.76	1.25	1.39	1.14	3.09
Isamel_14_AD	sigma_EUR_WES_122	0.54	0.53	0.01	0.41	1.73

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WES_122	Isamel_14_AD	0.00	2.30	3.83	3.62	1.85
Isamel_14_AD	sigma_EUR_WES_122	0.01	1.38	1.55	1.60	1.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_EUR_WES_122	122	121	RFPL2
Isamel_14_AD	14	14