Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_EUR_WES_122 Exclusive	ad_tier1_36	1.33e-07	4.53e-08	3.52e-10	6.49e-10
ad_tier1_36 Exclusive	sigma_EUR_WES_122	7.56e-02	8.77e-02	7.79e-03	3.02e-03
sigma_EUR_WES_122 Exclusive	ad_tier1_36 Exclusive	1.84e-05	1.02e-06	1.28e-07	1.44e-08
ad_tier1_36 Exclusive	sigma_EUR_WES_122 Exclusive	3.04e-01	2.33e-01	4.65e-02	1.10e-02
sigma_EUR_WES_122 Exclusive	Overlap	5.60e-06	1.10e-02	3.84e-07	6.04e-07
ad_tier1_36 Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	9.14e-09
Overlap	Exclusives	3.69e-05	1.12e-04	1.53e-17	1.12e-06



Evaluating how well sigma_EUR_WES_122 genes are linked to ad_tier1_36 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WES_122 Exclusive	ad_tier1_36	0.85	3.79	6.34	4.39	6.76
ad_tier1_36 Exclusive	sigma_EUR_WES_122	0.60	3.65	2.72	2.94	3.74
sigma_EUR_WES_122 Exclusive	ad_tier1_36 Exclusive	0.83	3.35	6.05	3.49	5.90
ad_tier1_36 Exclusive	sigma_EUR_WES_122 Exclusive	0.58	2.89	1.54	2.45	3.21
sigma_EUR_WES_122 Exclusive	Overlap	0.99	3.01	2.96	2.78	3.24
ad_tier1_36 Exclusive	Overlap	1.00	3.04	3.46	3.28	3.73
Overlap	Exclusives	0.64	3.73	5.02	2.98	6.30

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WES_122 Exclusive	ad_tier1_36	0.02	24.22	36.99	36.49	22.32
ad_tier1_36 Exclusive	sigma_EUR_WES_122	0.03	31.99	27.17	17.89	34.73
sigma_EUR_WES_122 Exclusive	ad_tier1_36 Exclusive	0.01	13.14	23.37	18.47	36.65
ad_tier1_36 Exclusive	sigma_EUR_WES_122 Exclusive	0.02	21.07	14.50	19.14	16.98
sigma_EUR_WES_122 Exclusive	Overlap	0.01	13.40	23.71	29.54	10.28
ad_tier1_36 Exclusive	Overlap	0.10	226.72	178.72	333.53	184.12
Overlap	Exclusives	0.09	50.69	102.32	73.44	126.82

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_EUR_WES_122 Exclusive	118	117	RFPL2
ad_tier1_36 Exclusive	27	26	MS4A
Overlap	4	4