Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_EUR_WGS_ADC_95 Exclusive	TIER1_GS	1.95e-01	1.57e-01	1.02e-01	7.94e-03
TIER1_GS Exclusive	sigma_EUR_WGS_ADC_95	2.68e-01	1.01e-01	1.96e-02	5.28e-02
sigma_EUR_WGS_ADC_95 Exclusive	TIER1_GS Exclusive	4.36e-01	2.40e-01	3.13e-01	1.88e-02
TIER1_GS Exclusive	sigma_EUR_WGS_ADC_95 Exclusive	3.31e-01	2.01e-01	4.86e-02	2.25e-01
sigma_EUR_WGS_ADC_95 Exclusive	Overlap	2.82e-01	4.87e-01	2.02e-01	1.33e-02
TIER1_GS Exclusive	Overlap	2.74e-08	1.83e-09	1.83e-09	3.84e-07
Overlap	Exclusives	7.97e-04	7.37e-05	4.24e-16	1.09e-05



Evaluating how well sigma_EUR_WGS_ADC_95 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_ADC_95 Exclusive	TIER1_GS	0.68	1.25	2.31	1.69	2.76
TIER1_GS Exclusive	sigma_EUR_WGS_ADC_95	0.55	2.05	1.73	1.94	1.57
sigma_EUR_WGS_ADC_95 Exclusive	TIER1_GS Exclusive	0.66	0.94	1.64	1.09	2.80
TIER1_GS Exclusive	sigma_EUR_WGS_ADC_95 Exclusive	0.53	1.68	0.81	1.83	0.95
sigma_EUR_WGS_ADC_95 Exclusive	Overlap	0.85	1.66	1.49	1.60	2.61
TIER1_GS Exclusive	Overlap	1.00	2.85	2.81	2.58	3.45
Overlap	Exclusives	0.63	5.32	4.96	3.32	4.98

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_ADC_95 Exclusive	TIER1_GS	0.00	0.87	2.12	2.03	2.86
TIER1_GS Exclusive	sigma_EUR_WGS_ADC_95	0.01	2.13	7.93	6.01	3.07
sigma_EUR_WGS_ADC_95 Exclusive	TIER1_GS Exclusive	0.00	0.82	1.54	0.60	1.55
TIER1_GS Exclusive	sigma_EUR_WGS_ADC_95 Exclusive	0.01	0.72	0.75	0.40	0.97
sigma_EUR_WGS_ADC_95 Exclusive	Overlap	0.00	0.53	0.93	0.33	1.81
TIER1_GS Exclusive	Overlap	0.05	106.14	147.45	161.86	126.86
Overlap	Exclusives	0.03	22.87	48.70	22.01	25.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_EUR_WGS_ADC_95 Exclusive	91	89	CHURC1-FNTB;TMEM191C
TIER1_GS Exclusive	27	26	MS4A
Overlap	4	4