Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_EUR_WGS_ADC_95	Ismael_14_AD	6.38e-01	3.89e-01	3.53e-01	3.17e-03
Ismael_14_AD	sigma_EUR_WGS_ADC_95	5.32e-01	5.43e-01	1.47e-05	3.29e-01



Evaluating how well sigma_EUR_WGS_ADC_95 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_ADC_95	Ismael_14_AD	0.76	0.76	1.95	1.13	3.58
Ismael_14_AD	sigma_EUR_WGS_ADC_95	0.53	1.77	1.04	1.08	1.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_ADC_95	Ismael_14_AD	0.00	0.58	3.14	1.85	6.61
Ismael_14_AD	sigma_EUR_WGS_ADC_95	0.01	0.52	1.15	1.25	1.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_EUR_WGS_ADC_95	95	93	CHURC1-FNTB;TMEM191C
Ismael_14_AD	14	14