Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_EUR_WGS_ADC_46_z_3_5 Exclusive	tier1_31	4.28e-01	2.63e-01	4.75e-01	7.84e-03
tier1_31 Exclusive	sigma_EUR_WGS_ADC_46_z_3_5	6.34e-01	6.59e-01	2.82e-01	4.36e-01
sigma_EUR_WGS_ADC_46_z_3_5 Exclusive	tier1_31 Exclusive	7.43e-01	4.84e-01	7.30e-01	7.62e-02
tier1_31 Exclusive	sigma_EUR_WGS_ADC_46_z_3_5 Exclusive	6.89e-01	9.71e-01	4.91e-01	8.97e-01
sigma_EUR_WGS_ADC_46_z_3_5 Exclusive	Overlap	4.30e-01	3.27e-01	4.62e-01	6.85e-02
tier1_31 Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	3.84e-07
Overlap	Exclusives	1.82e-06	1.46e-07	1.47e-15	2.23e-09



Evaluating how well sigma_EUR_WGS_ADC_46_z_3_5 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_ADC_46_z_3_5 Exclusive	tier1_31	0.62	0.27	0.52	0.54	2.41
tier1_31 Exclusive	sigma_EUR_WGS_ADC_46_z_3_5	0.56	0.68	1.24	1.14	1.34
sigma_EUR_WGS_ADC_46_z_3_5 Exclusive	tier1_31 Exclusive	0.59	-0.05	0.01	0.09	1.58
tier1_31 Exclusive	sigma_EUR_WGS_ADC_46_z_3_5 Exclusive	0.52	0.13	0.18	0.29	0.37
sigma_EUR_WGS_ADC_46_z_3_5 Exclusive	Overlap	0.81	1.27	1.38	1.08	2.56
tier1_31 Exclusive	Overlap	1.00	2.74	2.61	2.78	3.37
Overlap	Exclusives	0.72	4.81	6.25	4.14	6.81

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_ADC_46_z_3_5 Exclusive	tier1_31	0.00	-0.21	-0.28	-0.04	0.24
tier1_31 Exclusive	sigma_EUR_WGS_ADC_46_z_3_5	0.01	5.56	10.66	11.37	2.15
sigma_EUR_WGS_ADC_46_z_3_5 Exclusive	tier1_31 Exclusive	0.00	-0.38	-0.60	-0.30	0.14
tier1_31 Exclusive	sigma_EUR_WGS_ADC_46_z_3_5 Exclusive	0.00	-0.19	-0.27	-0.19	-0.23
sigma_EUR_WGS_ADC_46_z_3_5 Exclusive	Overlap	0.00	0.55	0.77	0.29	2.57
tier1_31 Exclusive	Overlap	0.05	99.64	151.64	131.98	31.16
Overlap	Exclusives	0.05	64.23	78.73	68.34	64.85

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_EUR_WGS_ADC_46_z_3_5 Exclusive	42	40	CHURC1-FNTB;TMEM191C
tier1_31 Exclusive	27	26	MS4A
Overlap	4	4