Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_EUR_WGS_LOAD_46_z_3_5	Ismael_14_AD	2.00e-01	6.20e-01	3.13e-01	1.95e-02
Ismael_14_AD	sigma_EUR_WGS_LOAD_46_z_3_5	1.97e-01	7.94e-01	1.77e-02	7.71e-01



Evaluating how well sigma_EUR_WGS_LOAD_46_z_3_5 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_LOAD_46_z_3_5	Ismael_14_AD	0.70	0.94	0.86	0.61	2.56
Ismael_14_AD	sigma_EUR_WGS_LOAD_46_z_3_5	0.53	0.54	0.90	0.41	0.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_LOAD_46_z_3_5	Ismael_14_AD	0.00	0.48	0.02	-0.05	0.34
Ismael_14_AD	sigma_EUR_WGS_LOAD_46_z_3_5	0.00	-0.17	0.73	0.10	-0.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_EUR_WGS_LOAD_46_z_3_5	46	46	
Ismael_14_AD	14	14