Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_EUR_WGS_LOAD_97_z_3	Ismael_14_AD	4.79e-02	6.72e-02	2.64e-02	1.72e-04
Ismael_14_AD	sigma_EUR_WGS_LOAD_97_z_3	5.18e-01	8.36e-01	1.77e-04	5.62e-01



Evaluating how well sigma_EUR_WGS_LOAD_97_z_3 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_LOAD_97_z_3	Ismael_14_AD	0.76	1.28	2.26	1.51	3.56
Ismael_14_AD	sigma_EUR_WGS_LOAD_97_z_3	0.51	1.53	0.64	0.27	0.33

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_LOAD_97_z_3	Ismael_14_AD	0.00	0.76	1.48	0.61	0.59
Ismael_14_AD	sigma_EUR_WGS_LOAD_97_z_3	0.01	1.66	0.72	0.52	0.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_EUR_WGS_LOAD_97_z_3	97	97	
Ismael_14_AD	14	14