Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_EUR_WGS_LOAD_97_z_3	TIER1_GS	8.59e-01	9.71e-01	6.79e-01	1.10e-01
TIER1_GS	sigma_EUR_WGS_LOAD_97_z_3	1.58e-02	8.33e-01	6.52e-01	8.12e-01



Evaluating how well sigma_EUR_WGS_LOAD_97_z_3 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_LOAD_97_z_3	TIER1_GS	0.59	-0.10	-0.21	0.12	1.95
TIER1_GS	sigma_EUR_WGS_LOAD_97_z_3	0.51	-0.35	0.26	-0.04	0.17

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_LOAD_97_z_3	TIER1_GS	0.00	-0.30	-0.54	-0.14	0.92
TIER1_GS	sigma_EUR_WGS_LOAD_97_z_3	0.01	-0.38	-0.07	-0.03	0.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_EUR_WGS_LOAD_97_z_3	97	97	
TIER1_GS	31	30	MS4A