Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_EUR_WGS_EOAD_109_z_3 Exclusive	tier1_31	1.69e-02	1.07e-02	6.09e-02	1.12e-03
tier1_31 Exclusive	sigma_EUR_WGS_EOAD_109_z_3	1.21e-01	1.38e-01	2.97e-02	1.36e-01
sigma_EUR_WGS_EOAD_109_z_3 Exclusive	tier1_31 Exclusive	4.30e-02	9.96e-03	4.21e-02	3.26e-03
tier1_31 Exclusive	sigma_EUR_WGS_EOAD_109_z_3 Exclusive	2.10e-01	3.02e-01	5.48e-02	3.02e-01
sigma_EUR_WGS_EOAD_109_z_3 Exclusive	Overlap	1.02e-01	1.46e-01	1.41e-01	1.80e-01
tier1_31 Exclusive	Overlap	9.85e-05	1.48e-03	9.85e-05	9.85e-05
Overlap	Exclusives	1.14e-04	1.85e-04	8.43e-06	1.82e-04



Evaluating how well sigma_EUR_WGS_EOAD_109_z_3 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_EOAD_109_z_3 Exclusive	tier1_31	0.70	1.80	2.65	1.47	3.95
tier1_31 Exclusive	sigma_EUR_WGS_EOAD_109_z_3	0.54	1.51	1.57	1.49	1.38
sigma_EUR_WGS_EOAD_109_z_3 Exclusive	tier1_31 Exclusive	0.69	1.62	2.21	1.72	3.07
tier1_31 Exclusive	sigma_EUR_WGS_EOAD_109_z_3 Exclusive	0.53	1.58	0.89	1.36	1.07
sigma_EUR_WGS_EOAD_109_z_3 Exclusive	Overlap	0.81	1.50	1.62	1.58	1.38
tier1_31 Exclusive	Overlap	1.00	2.94	2.14	2.55	2.42
Overlap	Exclusives	0.61	2.36	4.79	2.68	4.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_EOAD_109_z_3 Exclusive	tier1_31	0.00	1.07	1.82	1.05	3.35
tier1_31 Exclusive	sigma_EUR_WGS_EOAD_109_z_3	0.01	4.44	2.55	2.28	4.21
sigma_EUR_WGS_EOAD_109_z_3 Exclusive	tier1_31 Exclusive	0.00	0.99	1.31	1.52	2.64
tier1_31 Exclusive	sigma_EUR_WGS_EOAD_109_z_3 Exclusive	0.01	2.25	2.10	2.25	0.91
sigma_EUR_WGS_EOAD_109_z_3 Exclusive	Overlap	0.00	0.63	0.47	0.18	-0.06
tier1_31 Exclusive	Overlap	0.05	327.93	50.55	188.17	207.21
Overlap	Exclusives	0.03	21.69	43.44	23.42	34.94

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_EUR_WGS_EOAD_109_z_3 Exclusive	107	107	
tier1_31 Exclusive	29	28	MS4A
Overlap	2	2