Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_EUR_WGS_EOAD_109_z_3 Exclusive	Ismael_14_AD	1.22e-01	8.89e-02	1.57e-01	9.42e-04
Ismael_14_AD Exclusive	sigma_EUR_WGS_EOAD_109_z_3	3.18e-01	4.21e-02	2.97e-08	3.68e-02
sigma_EUR_WGS_EOAD_109_z_3 Exclusive	Ismael_14_AD Exclusive	2.13e-01	1.27e-01	1.93e-01	1.49e-03
Ismael_14_AD Exclusive	sigma_EUR_WGS_EOAD_109_z_3 Exclusive	1.99e-01	4.48e-02	1.09e-07	6.43e-02
sigma_EUR_WGS_EOAD_109_z_3 Exclusive	Overlap	1.39e-01	2.77e-01	2.97e-01	2.38e-01
Ismael_14_AD Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	4.48e-06	7.93e-03	6.65e-09	9.22e-03



Evaluating how well sigma_EUR_WGS_EOAD_109_z_3 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_EOAD_109_z_3 Exclusive	Ismael_14_AD	0.79	1.90	3.11	1.64	3.77
Ismael_14_AD Exclusive	sigma_EUR_WGS_EOAD_109_z_3	0.57	5.05	2.95	3.08	2.71
sigma_EUR_WGS_EOAD_109_z_3 Exclusive	Ismael_14_AD Exclusive	0.79	1.55	2.44	1.44	3.92
Ismael_14_AD Exclusive	sigma_EUR_WGS_EOAD_109_z_3 Exclusive	0.56	4.72	2.92	2.71	1.99
sigma_EUR_WGS_EOAD_109_z_3 Exclusive	Overlap	0.89	1.65	1.26	1.17	1.40
Ismael_14_AD Exclusive	Overlap	1.00	5.61	1.58	2.15	1.90
Overlap	Exclusives	0.58	1.61	3.34	1.66	3.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_EOAD_109_z_3 Exclusive	Ismael_14_AD	0.00	5.13	10.75	4.04	0.43
Ismael_14_AD Exclusive	sigma_EUR_WGS_EOAD_109_z_3	0.01	11.93	6.70	6.60	8.18
sigma_EUR_WGS_EOAD_109_z_3 Exclusive	Ismael_14_AD Exclusive	0.00	5.48	8.28	2.59	14.80
Ismael_14_AD Exclusive	sigma_EUR_WGS_EOAD_109_z_3 Exclusive	0.01	5.32	3.18	1.95	1.41
sigma_EUR_WGS_EOAD_109_z_3 Exclusive	Overlap	0.00	1.18	0.24	0.10	-0.02
Ismael_14_AD Exclusive	Overlap	0.25	1878.20	585.97	998.70	14.98
Overlap	Exclusives	0.02	12.90	23.77	12.10	14.61

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_EUR_WGS_EOAD_109_z_3 Exclusive	108	108	
Ismael_14_AD Exclusive	13	13	
Overlap	1	1